CLINICAL TRIALS AND OBSERVATIONS Bovine apolipoprotein B-100 is a dominant immunogen in therapeutic cell populations cultured in fetal calf serum in mice and humans

1Division of Therapeutic Proteins, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD; 2Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Japan; 3Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD; 4Transgenic Mouse Facility and Department of Physiology, Johns Hopkins University, School of Medicine, Baltimore, MD; 5Center for Applied Proteomics and Molecular Medicine, Department of Molecular and Microbiology, George Mason University, Manassas, VA; 6Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD; 7Laboratory of Molecular and Tumor Immunology, Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, OR; 8Glycobiology Research and Training Center and Departments of Medicine and Cellular and Molecular Medicine, University of California, San Diego; 9Animal Parasitic Diseases Laboratory, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD